Anti-Human Integrin beta 6 Reference Antibody (Sigvotatug, RUO) (HB251026)

Name: Anti-Human Integrin beta 6 Reference Antibody (Sigvotatug, RUO)
Brand: abinScience
SKU: HB251026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB251026
Description	Sigvotatug (HB251026) is a research-grade recombinant antibody targeting ITGB6. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	ITGB6, Integrin beta-6
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P18564
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2764774-90-3
Background	Integrin beta-6 (ITGB6) is a ~85 kDa protein. Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. 1. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 2. Ramsay, AG. et al. (2007) Cancer research 67, 5275-84. PMID: 17545607 3. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403 4. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742 5. Dong, X. et al. (2017) Nature 542, 55-59. PMID: 28117447
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Sigvotatug.

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Datasheet

Anti-Human Integrin beta 6 Reference Antibody (Sigvotatug, RUO).pdf

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Anti-Human Integrin beta 6 Reference Antibody (Sigvotatug, RUO) (HB251026)

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