| Catalog No. | HB251026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | ITGB6, Integrin beta-6 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P18564 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2764774-90-3 |
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| Background | Sigvotatug is an anti-ITGB6 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
• β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma., PMID:30653264
• Altered composition of the oral microbiome in integrin beta 6-deficient mouse., PMID:36117552
• Integrin subunit beta 6 is a potential diagnostic marker for acute kidney injury in patients with diabetic kidney disease: a single cell sequencing data analysis., PMID:39356055
• Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31., PMID:7959743
• CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability., PMID:38890650
• Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney., PMID:34516901
• ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta., PMID:24305999
• Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats., PMID:36307995
• Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle., PMID:24488487
• LncRNA SSTR5-AS1 promotes esophageal carcinoma through regulating ITGB6/JAK1/STAT3 signaling., PMID:39234955
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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