| Catalog No. | HB997066 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Isotype | Vibrio cholerae L-methionyl-cholix toxin fragment fused to human IL10 |
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| Expression system | Mammalian Cells |
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| Target | IL-10, IL10, Cytokine synthesis inhibitory factor, CSIF, Interleukin-10 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Purified by Nickel column. |
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| Accession | P22301 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2771192-33-5 |
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| Background | Vimekofusp is a recombinant IL-10 fusion protein that targets IL10RA and IL10RB.
• Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI., PMID:2161559
• Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes., PMID:1940799
• Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay., PMID:2145365
• Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI., PMID:1847510
• Interferon effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients., PMID:7560009
• Biological properties of interleukin 10., PMID:1385707
• Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity., PMID:1627494
• IL-10, a novel growth cofactor for mature and immature T cells., PMID:2124236
• Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10., PMID:1703785
• Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1., PMID:2173142
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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