| Catalog No. | HC359356 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Functional assay, Research in vivo |
|---|
| Isotype | Signal Regulatory protein .alpha. fusion protein with IgG1 Fc Fragment. |
|---|
| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
Leukocyte surface antigen CD47, CD47, Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Protein MER6, MER6 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q08722 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | ALX148, ALX-148, ALX148, CD47/SIRPa-blockingAgentALX148, SIRPaVariantALX148 |
|---|
| Background | Magrolimab is a first-in-class investigational monoclonal antibody against CD47 and macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, thus blocking the
• Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3., PMID:7998989
• Integrin-associated protein (CD47) and its ligands., PMID:11306274
• Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow., PMID:11156950
• Rh-related antigen CD47 is the signal-transducer integrin-associated protein., PMID:8294396
• Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling., PMID:16697668
• Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42., PMID:10891456
• Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells., PMID:8992983
• Molecular cloning and functional characterization of the pig homologue of integrin-associated protein (IAP/CD47)., PMID:12153520
• Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain., PMID:12736272
• The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi., PMID:10085089
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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