Anti-Human CD46 Reference Antibody (FOR46, RUO) (HB735016)

Name: Anti-Human CD46 Reference Antibody (FOR46, RUO)
Brand: abinScience
SKU: HB735016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HB735016
Description	Anti-Human CD46 Antibody (FOR46) (HB735016) is a research-grade recombinant antibody targeting CD46. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	FOR46
Expression system	Mammalian cells
Target	Trophoblast leukocyte common antigen, CD46, TLX, MCP, Membrane cofactor protein, MIC10
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P15529
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	FOR46, FOR46, FOR-46
Background	Membrane cofactor protein (CD46) is a ~43 kDa protein. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD46 Antibody (FOR46)
Bioactivity

Detects recombinant CD46 (Catalog No: HB735011) in indirect ELISA.

References

Datasheet

Anti-Human CD46 Reference Antibody (FOR46, RUO).pdf

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Recombinant Proteins

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Anti-Human CD46 Reference Antibody (FOR46, RUO) (HB735016)

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