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Research Grade Revtebercept (HB265046)

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Overview
Catalog No.HB265046
Description
Research Grade Revtebercept (HB265046) is a monoclonal antibody detecting VEGFR1/Flt-1.
Species reactivityHuman
ApplicationsELISA, FCM, Functional assay
ClonalityMonoclonal
IsotypeVGFR1-Fc
Expression system Mammalian cells
Nature Recombinant
Target EC:2.7.10.1, FLT, FLT-1, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor
Endotoxin level < 10 EU/mg as determined by LAL method.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P17948
Form Liquid
Storage buffer 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate NamesCAS: 3061548-52-2
Background

Vascular endothelial growth factor receptor 1 (FLT1/VEGFR1) is a ~150 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific.

1. Lesslie, DP. et al. (2006) British journal of cancer 94, 1710-7. PMID: 16685275
Note For research use only. Not suitable for clinical or therapeutic use.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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