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Anti-Human TNF RII/TNFRSF1B Reference Antibody (Zimlekitug, RUO) (HB070096)

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  • 1mg
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Overview
Catalog No.HB070096
Description
Anti-Human TNF RII/TNFRSF1B Reference Antibody (Zimlekitug, RUO) (HB070096) is a human monoclonal antibody detecting TNF RII/TNFRSF1B.
Species reactivityHuman
ApplicationsELISA, FCM, Functional assay
Host speciesHuman
ClonalityMonoclonal
IsotypeIgG1, lambda2
Expression system Mammalian cells
Nature Recombinant
Target CD120b, Etanercept, TBP-2, TBPII, TNF-R2, TNF-RII, TNFBR, TNFR-II, TNFR2, TNFRSF1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor superfamily member 1b, membrane form, Tumor necrosis factor receptor type II, Tumor necrosis factor-binding protein 2, p75, p80 TNF-alpha receptor
Endotoxin level < 10 EU/mg as determined by LAL method.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P20333
Form Liquid
Storage buffer 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate NamesCAS: 3079497-57-4
Background

Tumor necrosis factor receptor superfamily member 1B (CD120b/TNFR2) is a ~48 kDa protein. Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity.

Note For research use only. Not suitable for clinical or therapeutic use.
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