Human ATP8B1 Recombinant Protein (N-His) (HC936012)

Name: Human ATP8B1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC936012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC936012
Description	Recombinant Human ATP8B1 Protein, N-His (HC936012) expressed in E. coli, spanning Arg412-Lys949. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O43520
Protein length	Arg412-Lys949
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	63.88 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ATP8B1, ATPIC, ATPase class I type 8B member 1, EC:7.6.2.1, FIC1, Familial intrahepatic cholestasis type 1, P4-ATPase flippase complex alpha subunit ATP8B1, PFIC, Phospholipid-transporting ATPase IC
Background	Phospholipid-transporting ATPase IC is a ~143 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane. Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2. 1. Paulusma, CC. et al. (2008) Hepatology (Baltimore, Md.) 47, 268-78. PMID: 17948906 2. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773 3. Verhulst, PM. et al. (2010) Hepatology (Baltimore, Md.) 51, 2049-60. PMID: 20512993 4. van der Mark, VA. et al. (2014) Biochimica et biophysica acta 1842, 2378-86. PMID: 25239307 5. van der Mark, VA. et al. (2016) Biochimica et biophysica acta 1863, 2280-8. PMID: 27301931 6. Muñoz-Martínez, F. et al. (2010) Biochemical pharmacology 80, 793-800. PMID: 20510206
Note	For research use only

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Human ATP8B1 Recombinant Protein (N-His).pdf

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Human ATP8B1 Recombinant Protein (N-His) (HC936012)

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