Human ZDHHC1 Recombinant Protein (N-His-KSI) (HD005012)

Name: Human ZDHHC1 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HD005012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD005012
Description	Recombinant Human ZDHHC1 Protein, N-His-KSI (HD005012) expressed in E. coli, spanning His263-Ser485. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q8WTX9
Protein length	His263-Ser485
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	41.60 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C16orf1, DHHC domain-containing cysteine-rich protein 1, DHHC-1, EC:2.3.1.225, Palmitoyltransferase ZDHHC1, ZDHHC1, ZNF377, Zinc finger DHHC domain-containing protein 1, Zinc finger protein 377
Background	Palmitoyltransferase ZDHHC1 is a ~54 kDa protein. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3. Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation. Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7. 1. Nie, L. et al. (2024) Molecular cell 84, 3336-3353.e7. PMID: 39173637
Note	For research use only

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Datasheet

Human ZDHHC1 Recombinant Protein (N-His-KSI).pdf

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Human ZDHHC1 Recombinant Protein (N-His-KSI) (HD005012)

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