Mouse SIGLEC10 Recombinant Protein (C-Fc) (MV244011)

Name: Mouse SIGLEC10 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MV244011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MV244011
Description	Recombinant Mouse SIGLEC10 Protein, C-Fc (MV244011) expressed in Mammalian Cells, spanning Gln18-Lys543. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q80ZE3
Protein length	Gln18-Lys543
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	87.19 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	SIGLEC10, SLG2, Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2
Background	Sialic acid-binding Ig-like lectin 10 is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion. 1. Duong, BH. et al. (2010) The Journal of experimental medicine 207, 173-87. PMID: 20038598 2. Hoffmann, A. et al. (2007) Nature immunology 8, 695-704. PMID: 17572677 3. Pfrengle, F. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1724-31. PMID: 23836061 4. Chen, GY. et al. (2009) Science (New York, N.Y.) 323, 1722-5. PMID: 19264983 5. Jellusova, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 3618-27. PMID: 20200274 6. Ding, Y. et al. (2016) Nature immunology 17, 1167-75. PMID: 27548433
Note	For research use only

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Datasheet

Mouse SIGLEC10 Recombinant Protein (C-Fc).pdf

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Mouse SIGLEC10 Recombinant Protein (C-Fc) (MV244011)

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