Mouse B7-2/CD86 Recombinant Protein (C-His) (MW776021)

Name: Mouse B7-2/CD86 Recombinant Protein (C-His)
Brand: abinScience
SKU: MW776021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MW776021
Description	Recombinant Mouse CD86/B7-2 Protein, C-His (MW776021) expressed in Mammalian Cells, spanning Val26-Glu245. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P42082
Protein length	Val26-Glu245
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	27.94 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Activation B7-2 antigen, B70, BU63, CD28LG2, CD86, CTLA-4 counter-receptor B7.2, FUN-1, T-lymphocyte activation antigen CD86
Background	T-lymphocyte activation antigen CD86 is a ~34 kDa protein. Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. 1. Lucas, CR. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 723-36. PMID: 23241883 2. Freeman, GJ. et al. (1993) The Journal of experimental medicine 178, 2185-92. PMID: 7504059 3. Chen, C. et al. (1994) Journal of immunology (Baltimore, Md. : 1950) 152, 4929-36. PMID: 7513726
Note	For research use only

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Datasheet

Mouse B7-2/CD86 Recombinant Protein (C-His).pdf

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Mouse B7-2/CD86 Recombinant Protein (C-His) (MW776021)

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