Human PDE8A Recombinant Protein (N-His) (HD652012)

Name: Human PDE8A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD652012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD652012
Description	Recombinant Human PDE8A Protein, N-His (HD652012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O60658
Protein length	Ser480-Glu829
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.1.4.53, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A
Background	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is a ~93 kDa protein. Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. 1. Wang, H. et al. (2008) Biochemistry 47, 12760-8. PMID: 18983167 2. Brown, KM. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, E1533-42. PMID: 23509299
Note	For research use only

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Datasheet

Human PDE8A Recombinant Protein (N-His).pdf

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Human PDE8A Recombinant Protein (N-His) (HD652012)

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