Mouse SPN Recombinant Protein (N-His-KSI) (MB263012)

Name: Mouse SPN Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: MB263012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MB263012
Description	Recombinant Mouse SPN Protein, N-His-KSI (MB263012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P15702
Protein length	Asp20-Gly248
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	B-cell differentiation antigen LP-3, CD43, CD43 cytoplasmic tail, CD43-ct, CD43ct, Leukocyte sialoglycoprotein, Leukosialin, Ly-48, Lymphocyte antigen 48, Sialophorin, Spn
Background	Leukosialin is a ~40 kDa protein. Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. 1. Allenspach, EJ. et al. (2001) Immunity 15, 739-50. PMID: 11728336 2. Mody, PD. et al. (2007) Blood 110, 2974-82. PMID: 17638845 3. Cannon, JL. et al. (2011) Molecular biology of the cell 22, 954-63. PMID: 21289089 4. Cannon, JL. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 7385-93. PMID: 18490738 5. Velázquez, F. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 1305-1316. PMID: 26700769 6. van den Berg, TK. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 3637-40. PMID: 11238599
Note	For research use only

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Datasheet

Mouse SPN Recombinant Protein (N-His-KSI).pdf

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Mouse SPN Recombinant Protein (N-His-KSI) (MB263012)

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