Mouse HSD11B1 Recombinant Protein (N-His) (MB768012)

Name: Mouse HSD11B1 Recombinant Protein (N-His)
Brand: abinScience
SKU: MB768012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MB768012
Description	Recombinant Mouse HSD11B1 Protein, N-His (MB768012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P50172
Protein length	Glu25-Asn292
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	11-DH, 11-beta-HSD1, 11-beta-HSD1A/MCR, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase, 11beta-HSD1A, 7-oxosteroid reductase, Corticosteroid 11-beta-dehydrogenase isozyme 1, EC:1.1.1.146, EC:1.1.1.201, Hsd11, Hsd11b1, liver-type 11-beta-HSD
Background	11-beta-hydroxysteroid dehydrogenase 1 is a ~32 kDa protein. Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone in the presence of NADP(H). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes. Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids. It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates. Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others. 1. Mitić, T. et al. (2013) Biochemical pharmacology 86, 146-53. PMID: 23415904 2. Beck, KR. et al. (2019) The Journal of steroid biochemistry and molecular biology 190, 19-28. PMID: 30902677 3. Kotelevtsev, Y. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 14924-9. PMID: 9405715
Note	For research use only

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Mouse HSD11B1 Recombinant Protein (N-His).pdf

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Mouse HSD11B1 Recombinant Protein (N-His) (MB768012)

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