Mouse CD27 Ligand/TNFSF7/CD70 Recombinant Protein (N-His) (MB796012)

Name: Mouse CD27 Ligand/TNFSF7/CD70 Recombinant Protein (N-His)
Brand: abinScience
SKU: MB796012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MB796012
Description	Recombinant Mouse CD27 Protein, N-His (MB796012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P41272
Protein length	Lys30-Gln131
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD27, CD27 antigen, CD27L receptor, Cd27, T-cell activation antigen CD27, Tnfrsf7, Tumor necrosis factor receptor superfamily member 7
Background	CD27 antigen is a ~28 kDa protein. Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. 1. Hendriks, J. et al. (2000) Nature immunology 1, 433-40. PMID: 11062504 2. Nolte, MA. et al. (2005) Nature immunology 6, 412-8. PMID: 15723067 3. Englebert, K. et al. (2024) Cell reports 43, 113824. PMID: 38386557
Note	For research use only

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Datasheet

Mouse CD27 Ligand/TNFSF7/CD70 Recombinant Protein (N-His).pdf

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Mouse CD27 Ligand/TNFSF7/CD70 Recombinant Protein (N-His) (MB796012)

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