Mouse ZBED6 Recombinant Protein (N-His) (ME017012)

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Overview

Catalog No.	ME017012
Description	Recombinant Mouse ZBED6 Protein, N-His (ME017012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	D2EAC2
Protein length	Ser480-Asn779
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MGR, Muscle growth regulator, Zbed6, Zinc finger BED domain-containing protein 6
Background	Zinc finger BED domain-containing protein 6 is a ~109 kDa protein. Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific. Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP. Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females. Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription. Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2. 1. Markljung, E. et al. (2009) PLoS biology 7, e1000256. PMID: 20016685 2. Butter, F. et al. (2010) EMBO reports 11, 305-11. PMID: 20134481 3. Wang, X. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15997-6002. PMID: 24043816 4. Younis, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E2048-E2057. PMID: 29440408 5. Younis, S. et al. (2020) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34, 10250-10266. PMID: 32557799 6. Wang, X. et al. (2016) Scientific reports 6, 19006. PMID: 26750727
Note	For research use only

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Datasheet

Mouse ZBED6 Recombinant Protein (N-His).pdf

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Mouse ZBED6 Recombinant Protein (N-His) (ME017012)

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