Mouse TLR4 Recombinant Protein (N-His) (MT205012)

Name: Mouse TLR4 Recombinant Protein (N-His)
Brand: abinScience
SKU: MT205012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MT205012
Description	Recombinant Mouse TLR4 Protein, N-His (MT205012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9QUK6
Protein length	Asn26-Asn621
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD284, Lps, Tlr4, Toll-like receptor 4
Background	Toll-like receptor 4 is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. 1. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 20133493 2. Poltorak, A. et al. (1998) Science (New York, N.Y.) 282, 2085-8. PMID: 9851930 3. Qureshi, ST. et al. (1999) The Journal of experimental medicine 189, 615-25. PMID: 9989976 4. Tanimura, N. et al. (2014) International immunology 26, 307-14. PMID: 24380872
Note	For research use only

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Gaultheria leucocarpa var. cumingiana leaf essential oil enriched in methyl salicylate: Anti-inflammatory effect by targeting TLR4 and regulating the NF-κB/MAPK pathways

Datasheet

Mouse TLR4 Recombinant Protein (N-His).pdf

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Mouse TLR4 Recombinant Protein (N-His) (MT205012)

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