Mouse PDPN Recombinant Protein (N-His) (MV106022)

Name: Mouse PDPN Recombinant Protein (N-His)
Brand: abinScience
SKU: MV106022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MV106022
Description	Recombinant Mouse PDPN Protein, N-His (MV106022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q62011
Protein length	Gly23-Leu141
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	E11, Glycoprotein 38, Gp38, OTS-8, Ots8, PA2.26 antigen, Pdpn, Podoplanin, Transmembrane glycoprotein E11
Background	Podoplanin is a ~18 kDa protein. Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. 1. Kato, Y. et al. (2003) The Journal of biological chemistry 278, 51599-605. PMID: 14522983 2. Kaneko, M. et al. (2004) The Journal of biological chemistry 279, 38838-43. PMID: 15231832 3. Suzuki-Inoue, K. et al. (2007) The Journal of biological chemistry 282, 25993-6001. PMID: 17616532 4. Uhrin, P. et al. (2010) Blood 115, 3997-4005. PMID: 20110424 5. Astarita, JL. et al. (2015) Nature immunology 16, 75-84. PMID: 25347465 6. Scholl, FG. et al. (1999) Journal of cell science 112 ( Pt 24), 4601-13. PMID: 10574709 7. Ramirez, MI. et al. (2003) Developmental biology 256, 61-72. PMID: 12654292 8. Boucherot, A. et al. (2002) Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 17, 978-84. PMID: 12032185
Note	For research use only

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Datasheet

Mouse PDPN Recombinant Protein (N-His).pdf

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Mouse PDPN Recombinant Protein (N-His) (MV106022)

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