Mouse STAT1 Recombinant Protein (N-His) (MW746012)

Name: Mouse STAT1 Recombinant Protein (N-His)
Brand: abinScience
SKU: MW746012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MW746012
Description	Recombinant Mouse STAT1 Protein, N-His (MW746012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P42225
Protein length	Met1-Asn129
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Signal transducer and activator of transcription 1, Stat1
Background	Signal transducer and activator of transcription 1 is a ~87 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. 1. Hart, KC. et al. (2001) Molecular biology of the cell 12, 931-42. PMID: 11294897 2. Nair, JS. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 5971-6. PMID: 11972023 3. Krejci, P. et al. (2008) PloS one 3, e3961. PMID: 19088846 4. Perwitasari, O. et al. (2011) The Journal of biological chemistry 286, 44412-23. PMID: 22065572 5. Cirri, P. et al. (1997) Biochemical and biophysical research communications 239, 493-7. PMID: 9344858 6. He, K. et al. (2023) Cell 186, 3033-3048.e20. PMID: 37327784
Note	For research use only

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Mouse STAT1 Recombinant Protein (N-His).pdf

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Mouse STAT1 Recombinant Protein (N-His) (MW746012)

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