Feline IL-11 Recombinant Protein (C-His) (FB978011)

Name: Feline IL-11 Recombinant Protein (C-His)
Brand: abinScience
SKU: FB978011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	FB978011
Description	Feline IL-11 Recombinant Protein (C-His) (FB978011) expressed in Mammalian cells. Purity: >90% as determined by SDS-PAGE. by SDS-PAGE. Highlights ●Recombinant — Consistent lot-to-lot performance. ●High Purity — >90% as determined by SDS-PAGE. by SDS-PAGE for demanding downstream applications.
Expression system	Mammalian cells
Accession	XP_003997447.1
Protein length	Ala21-Leu199
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Felis catus (Cat) (Felis silvestris catus)
Nature	Recombinant
Endotoxin level	<0.1 EU/ug as determined by LAL method.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	22.06 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only

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Datasheet

Feline IL-11 Recombinant Protein (C-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Feline IL-11 Recombinant Protein (C-His) (FB978011)

Overview

Images

References

Datasheet

SDS