Anti-ADRM1 Polyclonal Antibody (HS705014)

Name: Anti-ADRM1 Polyclonal Antibody
Brand: abinScience
SKU: HS705014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HS705014

Description

Anti-ADRM1 Polyclonal Antibody (HS705014) is a rabbit polyclonal antibody detecting ADRM1 in ELISA, IHC, WB. Suitable for Bovine, Chicken, Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ADRM1 (Thr2-Asp407).

Target

Adhesion-regulating molecule 1, ADRM1, GP110, Rpn13 homolog, 110 kDa cell membrane glycoprotein, hRpn13, Gp110, Proteasome regulatory particle non-ATPase 13, ARM-1, Proteasomal ubiquitin receptor ADRM1

Purification

Purified by antigen affinity column.

Accession

Q16186

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Proteasomal ubiquitin receptor ADRM1 is a ~42 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation.

1. Jørgensen, JP. et al. (2006) Journal of molecular biology 360, 1043-52. PMID: 16815440

2. Yao, T. et al. (2006) Nature cell biology 8, 994-1002. PMID: 16906146

3. Hamazaki, J. et al. (2006) The EMBO journal 25, 4524-36. PMID: 16990800

4. Qiu, XB. et al. (2006) The EMBO journal 25, 5742-53. PMID: 17139257

5. Husnjak, K. et al. (2008) Nature 453, 481-8. PMID: 18497817

6. Jiao, L. et al. (2014) Protein & cell 5, 616-30. PMID: 24752541

7. Sahtoe, DD. et al. (2015) Molecular cell 57, 887-900. PMID: 25702870

8. Vander Linden, RT. et al. (2015) Molecular cell 57, 901-911. PMID: 25702872

Note

For research use only.

Images

References

Datasheet

Anti-ADRM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ADRM1 Polyclonal Antibody (HS705014)

Overview

Images

References

Datasheet

SDS

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