Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014)

Name: Anti-AIFM2/FSP1 Polyclonal Antibody
Brand: abinScience
SKU: HC098014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HC098014

Description

Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014) is a rabbit polyclonal antibody detecting AIFM2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant AIFM2/FSP1 (Met1-Pro373).

Target

Ferroptosis suppressor protein 1, FSP1, EC:1.6.5.-, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, AMID, p53-responsive gene 3 protein, AIFM2, AMID, PRG3

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9BRQ8, Q8BUE4, A5PJM4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ferroptosis suppressor protein 1 (AIFM2/FSP1) is a ~40 kDa protein. A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms.

1. Doll, S. et al. (2019) Nature 575, 693-698. PMID: 31634899

2. Bersuker, K. et al. (2019) Nature 575, 688-692. PMID: 31634900

3. Mishima, E. et al. (2022) Nature 608, 778-783. PMID: 35922516

4. Jin, DY. et al. (2023) Nature communications 14, 828. PMID: 36788244

5. Nakamura, T. et al. (2023) Nature structural & molecular biology 30, 1806-1815. PMID: 37957306

6. Li, W. et al. (2025) The EMBO journal 44, 1641-1662. PMID: 39881208

7. Zhang, S. et al. (2023) Cell research 33, 967-970. PMID: 37739993

8. Lan, H. et al. (2024) Cell discovery 10, 88. PMID: 39160155

9. Feng, S. et al. (2024) MedComm 5, e479. PMID: 38414669

10. Yang, JS. et al. (2025) Cell 188, 2569-2585.e20. PMID: 40233740

Note

For research use only

Images

References

Datasheet

Anti-AIFM2/FSP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014)

Overview

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References

Datasheet

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