Anti-AR Polyclonal Antibody (HY315014)

Name: Anti-AR Polyclonal Antibody
Brand: abinScience
SKU: HY315014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HY315014

Description

Anti-AR Polyclonal Antibody (HY315014) is a rabbit polyclonal antibody detecting AR in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Crocuta crocuta.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AR (Leu660-Thr919).

Target

Dihydrotestosterone receptor, NR3C4, DHTR, Androgen receptor, AR, Nuclear receptor subfamily 3 group C member 4

Purification

Purified by antigen affinity column.

Accession

P10275

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Androgen receptor (AR) is a ~99 kDa protein. Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

1. Yang, J. et al. (2009) Endocrine-related cancer 16, 139-53. PMID: 19022849

2. Cui, J. et al. (2011) Cellular and molecular life sciences : CMLS 68, 1091-103. PMID: 20812024

Note

For research use only.

Images

References

Datasheet

Anti-AR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-AR Polyclonal Antibody (HY315014)

Overview

Images

References

Datasheet

SDS

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