Anti-ATF6 Polyclonal Antibody (HB163024)

Name: Anti-ATF6 Polyclonal Antibody
Brand: abinScience
SKU: HB163024
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB163024

Description

Anti-ATF6 Polyclonal Antibody (HB163024) is a rabbit polyclonal antibody detecting ATF6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ATF6 (Ala547-Ser632).

Target

ATF6-alpha, Cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha, ATF6, Activating transcription factor 6 alpha

Purification

Purified by antigen affinity column.

Accession

P18850

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) is a ~74 kDa protein. Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR).

1. Haze, K. et al. (1999) Molecular biology of the cell 10, 3787-99. PMID: 10564271

2. Yoshida, H. et al. (2001) Molecular and cellular biology 21, 1239-48. PMID: 11158310

3. Yoshida, H. et al. (2001) Cell 107, 881-91. PMID: 11779464

Note

For research use only.

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