Anti-ATP11A Polyclonal Antibody (HB310014)

Name: Anti-ATP11A Polyclonal Antibody
Brand: abinScience
SKU: HB310014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HB310014

Description

Anti-ATP11A Polyclonal Antibody (HB310014) is a rabbit polyclonal antibody detecting Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human ATP11A (Asp387-Lys860).

Target

Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P98196, P98197

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Phospholipid-transporting ATPase IH (ATP11A) is a ~129 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Does not show flippase activity toward phosphatidylcholine (PC). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

1. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773

2. Naito, T. et al. (2015) The Journal of biological chemistry 290, 15004-17. PMID: 25947375

3. Segawa, K. et al. (2016) The Journal of biological chemistry 291, 762-72. PMID: 26567335

4. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007

5. Wang, J. et al. (2018) Scientific reports 8, 10795. PMID: 30018401

6. Chepurwar, S. et al. (2023) Human molecular genetics 32, 1083-1089. PMID: 36300302

7. Segawa, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34403372

Note

For research use only

Images

References

Datasheet

Anti-ATP11A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ATP11A Polyclonal Antibody (HB310014)

Overview

Images

References

Datasheet

SDS

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