Anti-BLVRB Polyclonal Antibody (HB818014)

Name: Anti-BLVRB Polyclonal Antibody
Brand: abinScience
SKU: HB818014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB818014

Description

Anti-BLVRB Polyclonal Antibody (HB818014) is a rabbit polyclonal antibody detecting BLVRB in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human BLVRB (Ala2-Gln206).

Target

FR, Green heme-binding protein, BLVRB, Flavin reductase (NADPH), FLR, NADPH-flavin reductase, GHBP, Biliverdin-IX beta-reductase, NADPH-dependent diaphorase, BVR-B, Biliverdin reductase B

Purification

Purified by antigen affinity column.

Accession

P30043

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Flavin reductase (NADPH) (BLVRB) is a ~22 kDa protein. Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase. Promotes fetal heme degradation during development. Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling. Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver.

1. Cunningham, O. et al. (2000) The Biochemical journal 345 Pt 2, 393-9. PMID: 10620517

2. Smith, LJ. et al. (2008) The Biochemical journal 411, 475-84. PMID: 18241201

3. Wu, S. et al. (2016) Blood 128, 699-709. PMID: 27207795

4. Zhou, HL. et al. (2023) Cell 186, 5812-5825.e21. PMID: 38056462

5. Yamaguchi, T. et al. (1994) The Journal of biological chemistry 269, 24343-8. PMID: 7929092

6. Cunningham, O. et al. (2000) The Journal of biological chemistry 275, 19009-17. PMID: 10858451

7. Li, Z. et al. (2018) The Biochemical journal 475, 1211-1223. PMID: 29500232

Note

For research use only.

Images

References

Datasheet

Anti-BLVRB Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-BLVRB Polyclonal Antibody (HB818014)

Overview

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References

Datasheet

SDS

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