Anti-BMP7 Polyclonal Antibody (HB664014)

Name: Anti-BMP7 Polyclonal Antibody
Brand: abinScience
SKU: HB664014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB664014

Description

Anti-BMP7 Polyclonal Antibody (HB664014) is a rabbit polyclonal antibody detecting BMP7 in ELISA, IHC, WB. Suitable for Human, Mouse, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human BMP7 (Asp30-His431).

Target

Bone morphogenetic protein 7, Eptotermin alfa, OP-1, OP1, BMP-7, Osteogenic protein 1, BMP7

Purification

Purified by antigen affinity column.

Accession

P18075

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Bone morphogenetic protein 7 (BMP7) is a ~49 kDa protein. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor.

1. Perron, JC. et al. (2019) Biology open 8. PMID: 31208997

2. Greenwald, J. et al. (2003) Molecular cell 11, 605-17. PMID: 12667445

3. Macías-Silva, M. et al. (1998) The Journal of biological chemistry 273, 25628-36. PMID: 9748228

4. Groppe, J. et al. (2002) Nature 420, 636-42. PMID: 12478285

5. Brunmeir, R. et al. (2016) PLoS genetics 12, e1006474. PMID: 27923061

6. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509

Note

For research use only.

Images

References

Datasheet

Anti-BMP7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-BMP7 Polyclonal Antibody (HB664014)

Overview

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References

Datasheet

SDS

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