Anti-Bovine ARRB1/ARRB2 Recombinant Antibody (Fab7) (BB908013)

Name: Anti-Bovine ARRB1/ARRB2 Recombinant Antibody (Fab7)
Brand: abinScience
SKU: BB908013
Price: 191 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

BB908013

Species reactivity

Bovine

Applications

ELISA

Host species

Human

Isotype

Fab - G1 - kappa

Clone ID

Fab7

Clonality

Monoclonal

Target

Beta-arrestin-1, Arrestin beta-1, Arrestin-2, ARRB1, Beta-arrestin-2, Arrestin beta-2, Arrestin-3, ARRB2, arrestin

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P17870, P32120

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Beta-arrestin-1 (ARRB1/ARRB2) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.

Note

For research use only

Images

References

Datasheet

Anti-Bovine ARRB1/ARRB2 Recombinant Antibody (Fab7).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Bovine ARRB1/ARRB2 Recombinant Antibody (Fab7) (BB908013)

Overview

Images

References

Datasheet

SDS

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