Anti-C1S Polyclonal Antibody (HY598014)

Name: Anti-C1S Polyclonal Antibody
Brand: abinScience
SKU: HY598014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY598014

Description

Anti-C1S Polyclonal Antibody (HY598014) is a rabbit polyclonal antibody detecting C1S in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C1S (Ile438-Pro685).

Target

C1 esterase, Complement C1s subcomponent, C1S, Complement component 1 subcomponent s

Purification

Purified by antigen affinity column.

Accession

P09871

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Complement C1s subcomponent is a ~76 kDa protein. Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway.

1. Lacroix, M. et al. (2001) The Journal of biological chemistry 276, 36233-40. PMID: 11445589

2. Kerr, FK. et al. (2005) The Journal of biological chemistry 280, 39510-4. PMID: 16169853

3. Kerr, MA. et al. (1978) The Biochemical journal 171, 99-107. PMID: 417728

4. Reboul, A. et al. (1979) FEBS letters 103, 156-61. PMID: 467643

5. McRae, BJ. et al. (1981) The Journal of biological chemistry 256, 12362-6. PMID: 6271784

6. Thielens, NM. et al. (1982) FEBS letters 141, 19-24. PMID: 6282646

7. Thielens, NM. et al. (1984) FEBS letters 165, 111-6. PMID: 6319179

8. Nagasawa, S. et al. (1977) Proceedings of the National Academy of Sciences of the United States of America 74, 2998-3001. PMID: 70787

9. Rossi, V. et al. (1998) The Journal of biological chemistry 273, 1232-9. PMID: 9422791

10. Zwarthoff, SA. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155115

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-C1S polyclonal antibody at 1ug/mL on recombinant C1S (Catalog No. HY598012).

References

Datasheet

Anti-C1S Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-C1S Polyclonal Antibody (HY598014)

Overview

Images

References

Datasheet

SDS

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