Anti-C9 Polyclonal Antibody (HY033014)

Name: Anti-C9 Polyclonal Antibody
Brand: abinScience
SKU: HY033014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HY033014

Description

Anti-C9 Polyclonal Antibody (HY033014) is a rabbit polyclonal antibody detecting C9 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C9 (Gln22-His265).

Target

Complement component C9, C9

Purification

Purified by antigen affinity column.

Accession

P02748

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Complement component C9 (Complement C9) is a ~63 kDa protein. Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore.

1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194

2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837

3. Dudkina, NV. et al. (2016) Nature communications 7, 10588. PMID: 26841934

4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168

5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328

6. Podack, ER. et al. (1982) The Journal of experimental medicine 156, 268-82. PMID: 6177822

7. Lassiter, HA. et al. (1997) Pediatric research 42, 128-36. PMID: 9212048

8. Witzel-Schlömp, K. et al. (1998) Immunogenetics 48, 144-7. PMID: 9634479

9. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456

10. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882

Note

For research use only.

Images

References

Datasheet

Anti-C9 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-C9 Polyclonal Antibody (HY033014)

Overview

Images

References

Datasheet

SDS

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