Anti-CALCRL Polyclonal Antibody (HS841014)

Name: Anti-CALCRL Polyclonal Antibody
Brand: abinScience
SKU: HS841014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HS841014

Description

Anti-CALCRL Polyclonal Antibody (HS841014) is a rabbit polyclonal antibody detecting CALCRL in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CALCRL (Glu23-Glu133).

Target

CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor

Purification

Purified by antigen affinity column.

Accession

Q16602

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767

2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864

3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685

4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797

Note

For research use only.

Images

References

Datasheet

Anti-CALCRL Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CALCRL Polyclonal Antibody (HS841014)

Overview

Images

References

Datasheet

SDS

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