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Anti-CBR1 Polyclonal Antibody (HB037014)

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Overview
Catalog No.HB037014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CBR1 (Met1-Trp277).
Target CBR1, CRN, Prostaglandin 9-ketoreductase, Carbonyl reductase [NADPH] 1, Short chain dehydrogenase/reductase family 21C member 1, PG-9-KR, Prostaglandin-E(2) 9-reductase, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, CBR, 20-beta-hydroxysteroid dehydrogenase, SDR21C1
Purification Purified by antigen affinity column.
Accession P16152
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Carbonyl reductase [NADPH] 1 (CBR1) is a ~30 kDa protein. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates.

1. Tanaka, M. et al. (2005) PLoS biology 3, e128. PMID: 15799708
2. Gonzalez-Covarrubias, V. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 973-80. PMID: 17344335
3. Bateman, R. et al. (2007) Organic & biomolecular chemistry 5, 3363-7. PMID: 17912391
4. Gonzalez-Covarrubias, V. et al. (2008) Pharmaceutical research 25, 1730-4. PMID: 18449627
5. Bateman, RL. et al. (2008) The Journal of biological chemistry 283, 35756-62. PMID: 18826943
6. Forrest, GL. et al. (1991) Molecular pharmacology 40, 502-7. PMID: 1921984
7. Wermuth, B. (1981) The Journal of biological chemistry 256, 1206-13. PMID: 7005231
8. Morgan, RA. et al. (2017) Scientific reports 7, 10633. PMID: 28878267
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CBR1 Polyclonal Antibody

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