Anti-CD152/CTLA4 Polyclonal Antibody (HB651014)

Name: Anti-CD152/CTLA4 Polyclonal Antibody
Brand: abinScience
SKU: HB651014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
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Overview

Catalog No.

HB651014

Description

Anti-CD152/CTLA4 Polyclonal Antibody (HB651014) is a rabbit polyclonal antibody detecting CD152 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD152/CTLA4 (Ala37-Asp161).

Target

CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4

Purification

Purified by antigen affinity column.

Accession

P16410

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy).

1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501

2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502

3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244

4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933

5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304

6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD152/CTLA4 polyclonal antibody at 1ug/mL on recombinant CD152/CTLA4 (Catalog No. HB651012).

References

Datasheet

Anti-CD152/CTLA4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-CD152/CTLA4 Polyclonal Antibody (HB651014)

Overview

Images

References

Datasheet

SDS

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