Anti-CD246/ALK Polyclonal Antibody (HV427014)

Name: Anti-CD246/ALK Polyclonal Antibody
Brand: abinScience
SKU: HV427014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HV427014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD246/ALK (Met1348-Ser1611).

Target

ALK, ALK tyrosine kinase receptor, CD246, Anaplastic lymphoma kinase

Purification

Purified by antigen affinity column.

Accession

Q9UM73

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

ALK tyrosine kinase receptor (CD246) is a ~176 kDa protein. Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis. Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response. In contrast, ALKAL1 is not a potent physiological ligand for ALK. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway.

1. Souttou, B. et al. (2001) The Journal of biological chemistry 276, 9526-31. PMID: 11121404

2. Simonitsch, I. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 1416-8. PMID: 11387242

3. Gouzi, JY. et al. (2005) Journal of cell science 118, 5811-23. PMID: 16317043

4. Degoutin, J. et al. (2007) FEBS letters 581, 727-34. PMID: 17274988

5. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385

6. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012

7. Reshetnyak, AV. et al. (2021) Nature 600, 153-157. PMID: 34819673

8. Borenäs, M. et al. (2021) The EMBO journal 40, e105784. PMID: 33411331

Note

For research use only.

Images

References

Datasheet

Anti-CD246/ALK Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CD246/ALK Polyclonal Antibody (HV427014)

Overview

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References

Datasheet

SDS

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