Anti-CD278/ICOS Polyclonal Antibody (HV702014)

Name: Anti-CD278/ICOS Polyclonal Antibody
Brand: abinScience
SKU: HV702014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV702014

Description

Anti-CD278/ICOS Polyclonal Antibody (HV702014) is a rabbit polyclonal antibody detecting CD278 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD278/ICOS (Glu21-Lys140).

Target

CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM

Purification

Purified by antigen affinity column.

Accession

Q9Y6W8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Inducible T-cell costimulator (CD278/ICOS) is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.

1. Hutloff, A. et al. (1999) Nature 397, 263-6. PMID: 9930702

2. Rujas, E. et al. (2020) Nature communications 11, 5066. PMID: 33033255

3. Pedros, C. et al. (2016) Nature immunology 17, 825-33. PMID: 27135603

4. Wan, Z. et al. (2020) Cellular & molecular immunology 17, 143-152. PMID: 30523347

Note

For research use only.

Images

References

Datasheet