Anti-CD281/TLR1 Polyclonal Antibody (HS759014)

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50ug
100ug

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS759014

Description

Anti-CD281/TLR1 Polyclonal Antibody (HS759014) is a rabbit polyclonal antibody detecting CD281 in ELISA, IHC, WB. Suitable for Human and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Bos taurus, Dasypus novemcinctus

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD281/TLR1 (Asn625-Lys786).

Target

Toll/interleukin-1 receptor-like protein, CD281, Toll-like receptor 1, TIL, KIAA0012, TLR1

Purification

Purified by antigen affinity column.

Accession

Q15399

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Toll-like receptor 1 (CD281/TLR1) is a ~90 kDa protein. Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

1. Lancioni, CL. et al. (2011) Infection and immunity 79, 663-73. PMID: 21078852

2. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD281/TLR1 polyclonal antibody at 1ug/mL on recombinant CD281/TLR1 (Catalog No. HS759012).

References

Datasheet