Anti-Human Neuropilin-1/NRP1 Polyclonal Antibody (HT070024)

Name: Anti-Human Neuropilin-1/NRP1 Polyclonal Antibody
Brand: abinScience
SKU: HT070024
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT070024

Description

Anti-CD304/NRP1 Polyclonal Antibody (HT070024) is a rabbit polyclonal antibody detecting CD304 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD304/NRP1 (Phe22-Ser641).

Target

NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor

Purification

Purified by antigen affinity column.

Accession

O14786

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Neuropilin-1 (CD304/NRP1) is a ~103 kDa protein. Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis.

1. Gagnon, ML. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 2573-8. PMID: 10688880

2. He, Z. et al. (1997) Cell 90, 739-51. PMID: 9288753

3. Soker, S. et al. (1998) Cell 92, 735-45. PMID: 9529250

4. Teesalu, T. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 16157-62. PMID: 19805273

5. Issitt, T. et al. (2019) iScience 11, 205-223. PMID: 30623799

Note

For research use only.

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References

Datasheet