Anti-TIM-3 Polyclonal Antibody (HV029014)

Name: Anti-TIM-3 Polyclonal Antibody
Brand: abinScience
SKU: HV029014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HV029014

Description

Anti-CD366/HAVCR2/TIM-3 Polyclonal Antibody (HV029014) is a rabbit polyclonal antibody detecting HAVCR2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD366/HAVCR2/TIM-3 (Ser22-Arg200).

Target

T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3

Purification

Purified by antigen affinity column.

Accession

Q8TDQ0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.

1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777

2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861

3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005

4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741

5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563

6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857

7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920

8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261

9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453

Note

For research use only.

Images

References

Datasheet

Anti-TIM-3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-TIM-3 Polyclonal Antibody (HV029014)

Overview

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References

Datasheet

SDS

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