Anti-CDK7 Polyclonal Antibody (HA660014)

Name: Anti-CDK7 Polyclonal Antibody
Brand: abinScience
SKU: HA660014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HA660014

Description

Anti-CDK7 Polyclonal Antibody (HA660014) is a rabbit polyclonal antibody detecting Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; CDK7; CAK; CAK1; CDKN7; MO15; STK1 in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, and Frog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human CDK7 (Met1-Phe346).

Target

Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; CDK7; CAK; CAK1; CDKN7; MO15; STK1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P50613, P51952, Q03147, P20911

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cyclin-dependent kinase 7 (CDK7) is a ~39 kDa protein. Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex.

1. Kershnar, E. et al. (1998) The Journal of biological chemistry 273, 34444-53. PMID: 9852112

2. Lolli, G. (2009) Nucleic acids research 37, 1260-8. PMID: 19136461

3. Nilson, KA. et al. (2015) Molecular cell 59, 576-87. PMID: 26257281

4. Ebmeier, CC. et al. (2017) Cell reports 20, 1173-1186. PMID: 28768201

5. Ko, LJ. et al. (1997) Molecular and cellular biology 17, 7220-9. PMID: 9372954

6. Schneider, E. et al. (1998) Oncogene 17, 2733-41. PMID: 9840937

Note

For research use only

Images

References

Datasheet

Anti-CDK7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-CDK7 Polyclonal Antibody (HA660014)

Overview

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References

Datasheet

SDS

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