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Anti-CHRNA4 Polyclonal Antibody (HW493014)

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Overview
Catalog No.HW493014
Description
Anti-CHRNA4 Polyclonal Antibody (HW493014) is a rabbit polyclonal antibody detecting CHRNA4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pan troglodytes.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CHRNA4 (Asn49-Leu242).
Target Neuronal acetylcholine receptor subunit alpha-4, NACRA4, CHRNA4
Purification Purified by antigen affinity column.
Accession P43681
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) is a ~69 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system.

1. Bondarenko, V. et al. (2012) Biochimica et biophysica acta 1818, 1261-8. PMID: 22361591
2. Morales-Perez, CL. et al. (2016) Nature 538, 411-415. PMID: 27698419
3. Walsh, RM. et al. (2018) Nature 557, 261-265. PMID: 29720657
4. Mazzaferro, S. et al. (2024) British journal of pharmacology 181, 1973-1992. PMID: 38454578
5. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 16835356
Note For research use only.
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Datasheet
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Formula
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Anti-CHRNA4 Polyclonal Antibody

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