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Anti-CIB1 Polyclonal Antibody (HV134014)

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Overview
Catalog No.HV134014
Description
Anti-CIB1 Polyclonal Antibody (HV134014) is a rabbit polyclonal antibody detecting CIB1 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Ovis aries, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CIB1 (Gly2-Leu191).
Target CIBP, CIB1, Calcium- and integrin-binding protein, Calcium and integrin-binding protein 1, KIP, SIP2-28, DNA-PKcs-interacting protein, PRKDCIP, Calmyrin, CIB, Kinase-interacting protein, SNK-interacting protein 2-28
Purification Purified by antigen affinity column.
Accession Q99828
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Calcium and integrin-binding protein 1 (CIB1) is a ~21 kDa protein. Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation.

1. de Jong, SJ. et al. (2018) The Journal of experimental medicine 215, 2289-2310. PMID: 30068544
2. Wu, CJ. et al. (2020) The Journal of biological chemistry 295, 16086-16099. PMID: 32917726
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CIB1 Polyclonal Antibody

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