Anti-CNOT6 Polyclonal Antibody (HV038014)

Name: Anti-CNOT6 Polyclonal Antibody
Brand: abinScience
SKU: HV038014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV038014

Description

Anti-CNOT6 Polyclonal Antibody (HV038014) is a rabbit polyclonal antibody detecting CNOT6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CNOT6 (Leu153-Arg557).

Target

KIAA1194, CCR4, CNOT6, CCR4a, CCR4 carbon catabolite repression 4-like, Cytoplasmic deadenylase, Carbon catabolite repressor protein 4 homolog, CCR4-NOT transcription complex subunit 6

Purification

Purified by antigen affinity column.

Accession

Q9ULM6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

CCR4-NOT transcription complex subunit 6 (CNOT6) is a ~63 kDa protein. Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA.

Note

For research use only.

Images

References

Datasheet