Anti-COPS2 Polyclonal Antibody (HX005014)

Name: Anti-COPS2 Polyclonal Antibody
Brand: abinScience
SKU: HX005014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HX005014

Description

Anti-COPS2 Polyclonal Antibody (HX005014) is a rabbit polyclonal antibody detecting COPS2 in ELISA, IHC, WB. Suitable for Danio rerio, Human, Mouse, Rat, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human COPS2 (Met1-Ala443).

Target

Signalosome subunit 2, CSN2, COPS2, Alien homolog, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP15, TRIP-15, JAB1-containing signalosome subunit 2, COP9 signalosome complex subunit 2, SGN2

Purification

Purified by antigen affinity column.

Accession

P61201

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

COP9 signalosome complex subunit 2 (COPS2) is a ~51 kDa protein. Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Note

For research use only.

Images

References

Datasheet

Anti-COPS2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-COPS2 Polyclonal Antibody (HX005014)

Overview

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References

Datasheet

SDS

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