Anti-COPS5 Polyclonal Antibody (HB373014)

Name: Anti-COPS5 Polyclonal Antibody
Brand: abinScience
SKU: HB373014
Price: 96 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HB373014

Description

Anti-COPS5 Polyclonal Antibody (HB373014) is a rabbit polyclonal antibody detecting COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; COPS5; CSN5; JAB1 in ELISA, IHC, WB. Suitable for Mouse, Human, Frog, and Zebrafish.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human COPS5 (Met1-Lys230).

Target

COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; COPS5; CSN5; JAB1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O35864, Q92905, Q6GLM9, Q6PC30

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

COP9 signalosome complex subunit 5 (COPS5) is a ~37 kDa protein. Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-COPS5 polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: PC-12 cell lysate

References

Datasheet

Anti-COPS5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-COPS5 Polyclonal Antibody (HB373014)

Overview

Images

References

Datasheet

SDS

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