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Anti-CYP17A1 Polyclonal Antibody (HY444014)

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Overview
Catalog No.HY444014
Description
Anti-CYP17A1 Polyclonal Antibody (HY444014) is a rabbit polyclonal antibody detecting CYP17A1 in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, Macaca mulatta, Pan troglodytes, and Papio cynocephalus.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CYP17A1 (Cys183-Thr508).
Target Steroid 17-alpha-hydroxylase/17, 20 lyase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Steroid 17-alpha-monooxygenase, 17-alpha-hydroxyprogesterone aldolase, CYP17A1, S17AH, Cytochrome P450c17, CYP17
Purification Purified by antigen affinity column.
Accession P05093
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.

1. DeVore, NM. et al. (2012) Nature 482, 116-9. PMID: 22266943
2. Petrunak, EM. et al. (2014) The Journal of biological chemistry 289, 32952-64. PMID: 25301938
3. Yoshimoto, FK. et al. (2016) The Journal of biological chemistry 291, 17143-64. PMID: 27339894
4. Auchus, RJ. et al. (1998) The Journal of biological chemistry 273, 3158-65. PMID: 9452426
5. Lee, SG. et al. (2023) Journal of inorganic biochemistry 240, 112085. PMID: 36640554
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-CYP17A1 Polyclonal Antibody

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