Anti-CYP26B1 Polyclonal Antibody (HV995014)

Name: Anti-CYP26B1 Polyclonal Antibody
Brand: abinScience
SKU: HV995014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV995014

Description

Anti-CYP26B1 Polyclonal Antibody (HV995014) is a rabbit polyclonal antibody detecting CYP26B1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human CYP26B1 (Thr97-Val512).

Target

CYP26A2, CYP26B1, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, EC:1.14.13.-, P450RAI2, Retinoic acid-metabolizing cytochrome

Endotoxin level

Please contact with the lab for this information.

Observed Molecular Weight

53 kDa

Purification

Purified by antigen affinity column.

Accession

Q9NR63

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cytochrome P450 26B1 is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination. Involved in the convertion of atRA to all-trans-4-oxo-RA.

1. White, JA. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 6403-8. PMID: 10823918

2. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119

3. Laue, K. et al. (2011) American journal of human genetics 89, 595-606. PMID: 22019272

Note

For research use only

Images

References

Datasheet

Anti-CYP26B1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CYP26B1 Polyclonal Antibody (HV995014)

Overview

Images

References

Datasheet

SDS

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