Anti-DES/Desmin Polyclonal Antibody (HB025014)

Name: Anti-DES/Desmin Polyclonal Antibody
Brand: abinScience
SKU: HB025014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HB025014

Description

Anti-DES/Desmin Polyclonal Antibody (HB025014) is a rabbit polyclonal antibody detecting Desmin in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DES/Desmin (Met1-Leu470).

Target

Desmin, DES

Purification

Purified by antigen affinity column.

Accession

P17661

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Desmin is a ~53 kDa protein. Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces.

1. Hnia, K. et al. (2015) Cell and tissue research 360, 591-608. PMID: 25358400

2. Brodehl, A. et al. (2013) Circulation. Cardiovascular genetics 6, 615-23. PMID: 24200904

3. Clemen, CS. et al. (2015) Acta neuropathologica 129, 297-315. PMID: 25394388

4. Brodehl, A. et al. (2016) Journal of molecular and cellular cardiology 91, 207-14. PMID: 26724190

Note

For research use only.

Images

References

Datasheet

Anti-DES/Desmin Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-DES/Desmin Polyclonal Antibody (HB025014)

Overview

Images

References

Datasheet

SDS

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