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Anti-Drosophila/Fruit fly Protein scalloped Polyclonal Antibody (ZD690014)

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Overview
Catalog No.ZD690014
Description
Anti-Drosophila/Fruit fly Protein scalloped Polyclonal Antibody (ZD690014) is a rabbit polyclonal antibody detecting Protein scalloped. Suitable for Fruit fly.
Species reactivityDrosophila melanogaster (Fruit fly)
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Drosophila/Fruit fly Protein scalloped (Trp220-Glu440).
Target Protein scalloped, sd
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P30052
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Protein scalloped is a ~49 kDa protein. Transcription factor which plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Sd promotes nuclear localization of Yki. Involved in the regulation of cell-specific gene expression during development, particularly in the differentiation of the nervous system.

Note For research use only
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Formula
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