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Anti-EFEMP2 Polyclonal Antibody (HF514014)

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Overview
Catalog No.HF514014
Description
Anti-EFEMP2 Polyclonal Antibody (HF514014) is a rabbit polyclonal antibody detecting EFEMP2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Cricetulus griseus.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human EFEMP2 (Ser26-Phe443).
Target EGF-containing fibulin-like extracellular matrix protein 2, Protein UPH1, Fibulin-4, FBLN4, EFEMP2, FIBL-4
Purification Purified by antigen affinity column.
Accession O95967
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) is a ~49 kDa protein. Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.

1. Sasaki, T. et al. (2016) Matrix biology : journal of the International Society for Matrix Biology 56, 132-149. PMID: 27339457
2. Cirulis, JT. et al. (2008) Biochemistry 47, 12601-13. PMID: 18973305
3. Choudhury, R. et al. (2009) The Journal of biological chemistry 284, 24553-67. PMID: 19570982
4. Djokic, J. et al. (2013) The Journal of biological chemistry 288, 22821-35. PMID: 23782690
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-EFEMP2 Polyclonal Antibody

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