Anti-FADD Polyclonal Antibody (HC591014)

Name: Anti-FADD Polyclonal Antibody
Brand: abinScience
SKU: HC591014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC591014

Description

Anti-FADD Polyclonal Antibody (HC591014) is a rabbit polyclonal antibody detecting FADD in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FADD (Ser12-Glu206).

Target

Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, MORT1, FAS-associating death domain-containing protein, FAS-associated death domain protein, FADD, Protein FADD

Purification

Purified by antigen affinity column.

Accession

Q13158

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

FAS-associated death domain protein (FADD) is a ~23 kDa protein. Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

1. Carrington, PE. et al. (2006) Molecular cell 22, 599-610. PMID: 16762833

2. Scott, FL. et al. (2009) Nature 457, 1019-22. PMID: 19118384

3. Wang, L. et al. (2010) Nature structural & molecular biology 17, 1324-9. PMID: 20935634

4. Li, S. et al. (2013) Nature 501, 242-6. PMID: 23955153

5. Pearson, JS. et al. (2013) Nature 501, 247-51. PMID: 24025841

6. Chinnaiyan, AM. et al. (1995) Cell 81, 505-12. PMID: 7538907

7. Medema, JP. et al. (1997) The EMBO journal 16, 2794-804. PMID: 9184224

Note

For research use only.

Images

References

Datasheet

Anti-FADD Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-FADD Polyclonal Antibody (HC591014)

Overview

Images

References

Datasheet

SDS

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