Anti-FBN1/Fibrillin-1 Polyclonal Antibody (HW833014)

Name: Anti-FBN1/Fibrillin-1 Polyclonal Antibody
Brand: abinScience
SKU: HW833014
Price: 168 USD
Availability: InStock

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Overview
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Overview

Catalog No.

HW833014

Description

Anti-FBN1/Fibrillin-1 Polyclonal Antibody (HW833014) is a rabbit polyclonal antibody detecting Fibrillin-1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FBN1/Fibrillin-1 (Ser2732-His2871).

Target

FBN, Fibrillin-1, FBN1

Purification

Purified by antigen affinity column.

Accession

P35555

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Fibrillin-1 (FBN1) is a ~312 kDa protein. Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components.

1. Lee, SS. et al. (2004) Structure (London, England : 1993) 12, 717-29. PMID: 15062093

2. Sakai, LY. et al. (1991) The Journal of biological chemistry 266, 14763-70. PMID: 1860873

3. Jensen, SA. et al. (2016) The Biochemical journal 473, 827-38. PMID: 27026396

4. Tiedemann, K. et al. (2013) Journal of cell science 126, 4187-94. PMID: 24039232

5. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887

6. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881

Note

For research use only.

Images

References

Datasheet

Anti-FBN1/Fibrillin-1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-FBN1/Fibrillin-1 Polyclonal Antibody (HW833014)

Overview

Images

References

Datasheet

SDS

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